TDRD3

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Description

The TDRD3 (tudor domain containing 3) is a protein-coding gene located on chromosome 13.

Tudor domain-containing protein 3 is a protein that in humans is encoded by the TDRD3 gene. It contains a Tudor domain and UBA protein domain and has three distinct Protein isoforms.

Tudor domain-containing protein 3 (TDRD3) acts as a scaffolding protein that binds dimethylarginine-containing proteins, playing a role in regulating the translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in these proteins. In the nucleus, it functions as a coactivator, recognizing and binding asymmetric dimethylation on core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a), and recruiting proteins to these arginine-methylated loci. In the cytoplasm, TDRD3 acts as an antiviral factor, participating in the assembly of stress granules alongside G3BP1.

TDRD3 is also known as -.

Associated Diseases

• schizophrenia 15
• common variable immunodeficiency
• combined immunodeficiency with skin granulomas
• severe combined immunodeficiency due to CTPS1 deficiency
• immunodeficiency 18
• hyper-IgM syndrome type 3
• severe combined immunodeficiency due to CARD11 deficiency
• Phelan-McDermid syndrome
• BENTA disease
• immunodeficiency, common variable, 14
• immunodeficiency 62
• reticular dysgenesis
• immunodeficiency 105
• agammaglobulinemia 10, autosomal dominant
• agammaglobulinemia 7, autosomal recessive
• FRAXF syndrome
• immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia