TCP1
Description
The TCP1 (t-complex 1) is a protein-coding gene located on chromosome 6.
The TCP1 gene in humans encodes the TCP-1 protein, also known as T-complex protein 1 subunit alpha. It is a molecular chaperone that is part of the TRiC complex, which consists of two identical stacked rings, each containing eight different proteins. The TRiC complex functions to fold unfolded polypeptides in an ATP-dependent manner within its central cavity. It is responsible for folding various proteins, including actin and tubulin. This gene produces multiple isoforms through alternative splicing.
TCP1, also known as T-complex protein 1 subunit alpha (TCP-1-alpha), CCT-alpha, or Chaperonin containing T-complex polypeptide 1 subunit 1, is a component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists in the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex, TCP1 may play a role in the assembly of BBSome, a complex involved in ciliogenesis that regulates the transport of vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
TCP1 is also known as CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha.
