TBRG4
Description
The TBRG4 (transforming growth factor beta regulator 4) is a protein-coding gene located on chromosome 7.
TBRG4, also known as CPR2 and FASTKD4, is a human protein encoded by the TBRG4 gene on chromosome 7. It belongs to the FASTKD family, which regulates mitochondrial energy balance under stress and cell cycle progression. TBRG4 is involved in cell proliferation during hematopoiesis and multiple myeloma.
TBRG4 shares structural characteristics with other FASTKD members, including an N-terminal mitochondrial targeting domain and three C-terminal domains: two FAST kinase-like domains (FAST_1 and FAST_2) and an RNA-binding domain (RAP). The mitochondrial targeting domain guides TBRG4 to the mitochondria, while the functions of the C-terminal domains are unknown, although RAP potentially binds RNA during trans-splicing. TBRG4 also contains multiple putative leucine zipper domains.
As a member of the FASTKD family, TBRG4 localizes to the mitochondria to regulate their energy balance, particularly under stressful conditions. While ubiquitously expressed in all tissues, TBRG4 is more abundant in skeletal muscle, heart muscle, and other tissues rich in mitochondria. It is also found in the bone marrow (BM) where it participates in hematopoiesis by inducing IL-6 and VEGF secretion, which stimulate cell proliferation and angiogenesis.
TBRG4 is also known as CPR2, FASTKD4.
