TAF9B
Description
The TAF9B (TATA-box binding protein associated factor 9b) is a protein-coding gene located on chromosome X.
TAF9B is a protein encoded by the TAF9B gene in humans. It is a subunit of the transcription factor IID (TFIID), which plays a critical role in the initiation of transcription by RNA polymerase II. TFIID is composed of the TATA-binding protein (TBP) and a group of proteins called TBP-associated factors (TAFs), including TAF9B. TAFs have diverse functions in transcription, including basal transcription, coactivation, promoter recognition, and modification of general transcription factors (GTFs). TAF9B shares some functions with TAF9, another subunit of TFIID, but also has distinct roles in the transcriptional regulatory process.
TAF9B is essential for cell viability and plays a crucial role in the regulation of gene expression. It is involved in both activating and repressing transcription of distinct, but partially overlapping sets of genes. TAF9B may also be involved in gene regulation associated with apoptosis. TAF9B is a component of several protein complexes involved in transcription, including the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex, and the STAGA transcription coactivator-HAT complex. Both TFIID and TFTC are essential for the regulation of RNA polymerase II-mediated transcription.
TAF9B is also known as DN-7, DN7, TAF9L, TAFII31L, TFIID-31.
Associated Diseases
- low grade glioma
- endometrial cancer
- dilated cardiomyopathy 1I
- colorectal cancer
- cancer
- Alzheimer disease
- osteoarthritis
