TAF7
Description
The TAF7 (TATA-box binding protein associated factor 7) is a protein-coding gene located on chromosome 5.
TAF7, also known as TAFII55, is a protein encoded by the TAF7 gene in humans. This intronless gene is located between the protocadherin beta and gamma gene clusters on chromosome 5. TAF7 is a component of the TFIID protein complex, which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors for transcription. TAF7 interacts with the largest TFIID subunit and multiple transcription activators. It is crucial for transcription by promoters targeted by RNA polymerase II. TAF7 binds to TAFII250 and inhibits its acetyltransferase activity. Although its exact role is unclear, studies have shown that TAF7 interacts with the C-jun pathway. The conserved region is situated towards the N-terminal of the protein, and crystallographic studies have revealed a significant hydrophobic pocket between TAF7 and TAF1, its main binding partner.
TAF7, also known as TAFII55, is a subunit of the TFIID complex, a crucial component in the initiation of RNA polymerase II-dependent transcription. TFIID recognizes and binds to promoters, both with and without a TATA box, through its subunit TBP, a TATA-box-binding protein. This binding facilitates the assembly of the pre-initiation complex (PIC). The TFIID complex includes TBP and various TBP-associated factors (TAFs), among them TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12, and TAF13. TAF7, together with TAF1 and TAF2, forms a subcomplex within TFIID that binds to promoter DNA. Interestingly, TAF7 is present in two distinct forms of the TFIID complex: one containing TAF10 (TFIID alpha) and another lacking TAF10 (TFIID beta).
TAF7 is also known as TAF2F, TAFII55.
