TAF5
Description
The TAF5 (TATA-box binding protein associated factor 5) is a protein-coding gene located on chromosome 10.
Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.
== Function == Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex.
== Interactions == TAF5 has been shown to interact with:
TAF6, TAF9, and TAF15, TATA binding protein.
The TFIID complex, a key player in RNA polymerase II-dependent transcription initiation, binds promoters with or without a TATA box through its TBP subunit. This binding promotes the formation of the pre-initiation complex (PIC). TAF5, a component of TFIID, is present in two modules: TFIID-A (along with TAF3 and TBP) and TFIID-B (with TAF8). TAF5 contributes to interactions between TFIID and TFIIF within the PIC.
TAF5 is also known as TAF(II)100, TAF2D, TAFII-100, TAFII100.
