TAF3
Description
The TAF3 (TATA-box binding protein associated factor 3) is a protein-coding gene located on chromosome 10.
Transcription initiation factor TFIID subunit 3 is a protein that in humans is encoded by the TAF3 gene.
The TAF3 protein is a subunit of the TFIID complex, which is essential for the initiation of RNA polymerase II-dependent transcription. TFIID recognizes and binds to promoters, both those with and without a TATA box, through its TBP subunit. TAF3, along with TAF5 and TBP, forms the TFIID-A module, a key component of the TFIID complex structure. TAF3 plays a role in muscle differentiation, as it is required, in complex with TBPL2, for the transformation of myoblasts into myocytes. The TAF3-TBPL2 complex replaces TFIID at specific promoters during the early stages of this differentiation process.
TAF3 is also known as TAF140, TAFII-140, TAFII140.
