TAAR8
Description
The TAAR8 (trace amine associated receptor 8) is a protein-coding gene located on chromosome 6.
TAAR8 is a protein encoded by the TAAR8 gene in humans. It is unique among trace amine-associated receptors in humans as it is known to be coupled with Gi/o proteins. Molecular modeling and docking studies have indicated that putrescine can bind to the binding pockets of both human TAAR6 and TAAR8 receptors. Like other G protein-coupled receptors (GPCRs), TAAR8 possesses seven transmembrane domains and transmits extracellular signals through heterotrimeric G proteins.
TAAR8 is an orphan receptor, meaning its specific ligand and function are not fully understood. It is a potential receptor for trace amines, which are biogenic amines found in low levels in mammals. While trace amines have established neurotransmitter roles in invertebrates, their vertebrate functions are still being investigated. They are thought to play a part in various physiological processes, but the details remain unclear.
TAAR8 is also known as GPR102, TA5, TAR5, TRAR5, TaR-5, TaR-8.
Associated Diseases
- endometrial cancer
- thyroid gland adenocarcinoma
- esophageal cancer
- ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome
- autosomal dominant limb-girdle muscular dystrophy type 1G
- cancer
- breast cancer
