TAAR5
Description
The TAAR5 (trace amine associated receptor 5) is a protein-coding gene located on chromosome 6.
Trace amine-associated receptor 5 is a protein that in humans is encoded by the TAAR5 gene. In vertebrates, TAAR5 is expressed in the olfactory epithelium. Human TAAR5 (hTAAR5) is a functional trace amine-associated receptor which acts as an olfactory receptor for tertiary amines. Trimethylamine and N,N-dimethylethylamine are full agonists of hTAAR5. The amber-woody fragrance timberol antagonizes this activity of trimethylamine. 3-Iodothyronamine is an inverse agonist of hTAAR5. Recent studies highlighted the significant role of TAAR5 in the central nervous system and periphery. Beta-galactosidase mapping of TAAR5 expression showed its localization not only in the glomeruli but also in deeper layers of olfactory bulb projecting to the limbic brain olfactory circuitry. Moreover, TAAR5 knockout mice show increased adult neurogenesis and elevated number of dopamine neurons. Also, it was observed statistically significant changes in osmotic erythrocyte fragility in TAAR5-KO mice.
TAAR5 is also known as PNR, taR-5.
Associated Diseases
- endometrial cancer
- thyroid gland adenocarcinoma
- low grade glioma
- schizophrenia
- bipolar disorder
- multiple sclerosis
- encephalitis
- cancer
- Parkinson disease
