TAAR2
Description
The TAAR2 (trace amine associated receptor 2) is a protein-coding gene located on chromosome 6.
TAAR2, formerly known as GPR58, is a protein encoded by the TAAR2 gene in humans. It's a G protein-coupled receptor, but its signaling mechanisms are still being investigated. TAAR2 is found in various tissues, including the cerebellum, olfactory sensory neurons, and white blood cells. It plays a role in white blood cell activation by trace amines in granulocytes. In mice, TAAR2 expression has been found in the olfactory bulb, limbic areas, midbrain, and somatosensory cortex. TAAR2 knockout mice exhibit altered dopamine and norepinephrine levels in the brain, suggesting its involvement in the regulation of monoamine systems.
TAAR2 is an orphan receptor, meaning its specific ligand and signaling pathway are not yet fully understood.
TAAR2 is also known as GPR58, taR-2.
