SYCP1
Description
The SYCP1 (synaptonemal complex protein 1) is a protein-coding gene located on chromosome 1.
Synaptonemal complex protein 1 is a protein involved in the synaptonemal complex during meiosis, that in humans is encoded by the SYCP1 gene.
SYCP1 is a crucial protein for proper chromosome pairing and synapsis during meiosis. It is a major component of the transverse filaments within synaptonemal complexes, structures that form between homologous chromosomes during meiotic prophase. SYCP1 is essential for the normal assembly of the central element of these complexes and plays a critical role in centromere pairing during meiosis. Its function is vital for the accurate synapsis of chromosomes during oocyte and spermatocyte development, ultimately contributing to normal male and female fertility.
SYCP1 is also known as CT8, HOM-TES-14, SCP-1, SCP1.
Associated Diseases
- esophageal cancer
- partial chromosome Y deletion
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failures 50
- spermatogenic failure 25
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 61
- spermatogenic failure, X-linked, 2
- spermatogenic failure 48
- ring chromosome Y
- spermatogenic failure 20
- spermatogenic failure 72
