SYCE2
Description
The SYCE2 (synaptonemal complex central element protein 2) is a protein-coding gene located on chromosome 19.
SYCE2 is a key component of the central element of synaptonemal complexes (SCs), structures that form between homologous chromosomes during meiotic prophase. SCs are essential for proper chromosome pairing, synapsis, and recombination. SYCE2 interacts with other proteins, like SYCP1, to assemble and stabilize the central element, potentially playing a role in recombination.
SYCE2 is also known as CESC1.
Associated Diseases
- glutaryl-CoA dehydrogenase deficiency
- type 2 diabetes mellitus
- esophageal cancer
- male infertility with teratozoospermia due to single gene mutation
