SVEP1
Description
The SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1) is a protein-coding gene located on chromosome 9.
SVEP1, also known as CCP module-containing protein 22, Polydom, Selectin-like osteoblast-derived protein, and Serologically defined breast cancer antigen NY-BR-38, is a protein containing Sushi, von Willebrand factor type A, EGF, and pentraxin domains. It is involved in a variety of cellular processes, including lymphatic vascular development, vasoconstriction, platelet activation, and epidermal development.
SVEP1 is essential for the proper development of lymphatic vessels during embryonic development. It contributes to the formation of the initial connection between lymphatic and venous vessels and ensures their close association. It also plays a role in the morphological development, alignment, and migration of lymphatic endothelial cells during embryonic development, possibly by regulating ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription. In addition, SVEP1 inhibits vasoconstriction by suppressing PRKCA-mediated calcium influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, likely through interactions with integrins. It also promotes platelet activation by interacting with PEAR1 and activating AKT/mTOR signaling. SVEP1 is involved in epidermal development and keratinocyte differentiation, independent of cell-cell adhesion. Furthermore, it may contribute to the initial attachment of stromal osteogenic cells and promote myoblast cell adhesion in the presence of integrin ITGA9:ITGB1.
SVEP1 is also known as C9orf13, CCP22, POLYDOM, SEL-OB, SELOB.
