SUZ12
Description
The SUZ12 (SUZ12 polycomb repressive complex 2 subunit) is a protein-coding gene located on chromosome 17.
SUZ12 is a human gene that encodes a zinc finger protein involved in chromatin silencing. It is found at the breakpoints of chromosomal translocations associated with endometrial stromal sarcoma. SUZ12 functions as part of the Polycomb Repressive Complex 2 (PRC2), potentially playing a role in chromatin silencing in conjunction with the HOTAIR ncRNA. Its zinc finger domain is thought to bind to the RNA molecule.
SUZ12 is a component of the Polycomb Repressive Complex 2 (PRC2), which is involved in gene silencing. PRC2 methylates histone H3 at lysine 9 (H3K9me) and lysine 27 (H3K27me), leading to transcriptional repression of target genes. PRC2 may also act as a platform for recruiting DNA methyltransferases, thus linking two epigenetic silencing systems. Genes repressed by PRC2 include HOXC8, HOXA9, MYT1, and CDKN2A.
SUZ12 is also known as CHET9, IMMAS, JJAZ1.
