SUV39H2


Description

The SUV39H2 (SUV39H2 histone lysine methyltransferase) is a protein-coding gene located on chromosome 10.

SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene. It functions as a histone-lysine N-methyltransferase.

SUV39H2 is a histone methyltransferase that specifically trimethylates lysine 9 of histone H3 using monomethylated H3 lysine 9 as a substrate. This trimethylation acts as a signal for epigenetic transcriptional repression by recruiting HP1 proteins (CBX1, CBX3, and/or CBX5) to methylated histones. SUV39H2 primarily functions in heterochromatin regions, playing a crucial role in establishing constitutive heterochromatin at pericentric and telomere regions. Trimethylation of H3 lysine 9 by SUV39H2 is also essential for directing DNA methylation at pericentric repeats. SUV39H2 interacts with RB1, targeting it to histone H3 and contributing to various processes like cell cycle regulation, transcriptional repression, and telomere length regulation. It might also participate in regulating higher-order chromatin organization during spermatogenesis. SUV39H2 is recruited by the large PER complex to the E-box elements of circadian target genes, such as PER2 and PER1, contributing to the conversion of local chromatin into a heterochromatin-like repressive state through H3 lysine 9 trimethylation.

SUV39H2 is also known as KMT1B.

Associated Diseases



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