SUPV3L1
Description
The SUPV3L1 (Suv3 like RNA helicase) is a protein-coding gene located on chromosome 10.
SUPV3L1, a human gene, encodes the ATP-dependent RNA helicase SUPV3L1, mitochondrial. This enzyme is crucial for mitochondrial RNA metabolism.
SUPV3L1 is a key enzyme in mitochondrial RNA metabolism. As a component of the mitochondrial degradosome (mtEXO) complex, it degrades double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. It is involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. SUPV3L1 is an ATPase and ATP-dependent multisubstrate helicase that can unwind double-stranded DNA and RNA, as well as RNA/DNA heteroduplexes in the 5'-to-3' direction. It plays a role in the RNA surveillance system in mitochondria, regulating the stability of mature mRNAs, removing aberrantly formed mRNAs, and rapidly degrading non-coding processing intermediates. SUPV3L1 is also implicated in recombination and chromatin maintenance pathways and may protect cells from apoptosis. It associates with mitochondrial DNA.
SUPV3L1 is also known as SUV3.
