SUPT6H


Description

The SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor) is a protein-coding gene located on chromosome 17.

Transcription elongation factor SPT6 is a protein that in humans is encoded by the SUPT6H gene.

SUPT6H, also known as hSPT6, plays a crucial role in regulating transcription elongation and mRNA processing. It binds to histone H3 and enhances transcription elongation by RNA polymerase II (RNAPII), also aiding in the activation of transcriptional elongation by the HIV-1 Tat protein. SUPT6H acts as a histone chaperone, transporting and splicing mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of RNAPII subunit RPB1 (POLR2A). This complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) and histone-modifying enzymes (like SETD2), ensuring proper mRNA splicing, efficient mRNA export, and elongation-coupled H3K36 methylation, a hallmark of active transcription. SUPT6H interacts with SETD1A to regulate class-switch recombination and somatic hypermutation through the formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. It promotes the activation of the myogenic gene program by removing the repressive H3K27me3 epigenetic mark through stabilizing the chromatin interaction of the H3K27 demethylase KDM6A.

SUPT6H is also known as SPT6, SPT6H, emb-5.

Associated Diseases


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