SUMO2

Description

The SUMO2 (small ubiquitin like modifier 2) is a protein-coding gene located on chromosome 17.

SUMO2 (Small ubiquitin-related modifier 2) is a protein encoded by the SUMO2 gene in humans. It belongs to the SUMO protein family, which are ubiquitin-like proteins involved in post-translational modifications. SUMO2 functions similarly to ubiquitin, attaching to target proteins, but unlike ubiquitin, which targets proteins for degradation, SUMO2 participates in various cellular processes, including nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO2 interacts with TRIM63 and CFAP298. Deep hypothermia, used in major cardiovascular procedures to protect the brain from ischemic injury, has been shown to activate SUMO1-3 conjugation in the brain.

SUMO2, a ubiquitin-like protein, can be attached to other proteins as a single unit or a chain linked by lysine residues. This attachment, known as sumoylation, requires a series of steps: activation by the E1 complex (SAE1-SAE2), linkage to the E2 enzyme (UBE2I), and promotion by an E3 ligase (such as PIAS1-4, RANBP2, CBX4, or ZNF451). Sumoylation plays a critical role in various cellular processes including nuclear transport, DNA replication and repair, mitosis, and signal transduction. Chains of SUMO2 can also be modified by polyubiquitination, which acts as a signal for protein degradation by the proteasome. SUMO2 regulates the sumoylation of SETX.

SUMO2 is also known as HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A.

Associated Diseases

WES Whole Exome Sequencing