SULT1C4
Description
The SULT1C4 (sulfotransferase family 1C member 4) is a protein-coding gene located on chromosome 2.
Sulfotransferase 1C4 is an enzyme encoded by the SULT1C4 gene in humans. Sulfotransferase enzymes are responsible for catalyzing the sulfate conjugation of various molecules, including hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are known for their diverse tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar across family members. SULT1C4 encodes a protein that belongs to the SULT1 subfamily, which transfers a sulfo moiety from PAPS to phenol-containing compounds.
Sulfotransferase 1C4 catalyzes the sulfate conjugation of phenolic compounds using 3'-phospho-5'-adenylyl sulfate (PAPS) as a sulfonate donor. It also sulfonates estrogenic compounds, with a preference for dietary flavonoids (phytoestrogens) and environmental estrogens like bisphenol A over 17beta-estradiol (E2). Additionally, it mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines.
SULT1C4 is also known as SULT1C, SULT1C2.
