SULT1C2
Description
The SULT1C2 (sulfotransferase family 1C member 2) is a protein-coding gene located on chromosome 2.
Sulfotransferase 1C2 is an enzyme encoded by the SULT1C2 gene in humans. Sulfotransferase enzymes play a role in the sulfate conjugation of hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes exhibit variations in their tissue distribution and substrate specificity. The gene structure, including the number and length of exons, is similar among family members. SULT1C2 encodes a protein belonging to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Sulfotransferase 1C2 (SULT1C2) is an enzyme that catalyzes the sulfate conjugation of phenolic compounds. It utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor. SULT1C2 does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol. The enzyme catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene, leading to highly reactive intermediates that can form DNA adducts and potentially cause mutagenesis.
SULT1C2 is also known as ST1C1, ST1C2, SULT1C1, humSULTC2.
