STRA8
Description
The STRA8 (stimulated by retinoic acid 8) is a protein-coding gene located on chromosome 7.
STRA8 is a crucial factor initiating meiosis in both male and female germ cells. In females, it operates downstream of ZGLP1, driving the meiotic program by facilitating pre-meiotic DNA replication and subsequent events within the meiotic prophase. In males, it promotes spermatogonial differentiation alongside its role in initiating meiosis. STRA8 forms a complex with MEIOSIN, directly activating the transcription of specific meiotic genes. This activation plays a pivotal role in shifting the cell cycle from mitosis to meiosis.
STRA8 is also known as -.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 61
- spermatogenic failure 48
- spermatogenic failures 50
- spermatogenic failure 25
- spermatogenic failure 8
- spermatogenic failure 22
- spermatogenic failure 52
- spermatogenic failure 23
- spermatogenic failure 70
- spermatogenic failure, X-linked, 2
- spermatogenic failure 1
- spermatogenic failure 51
- spermatogenic failure 29
