STAP2
Description
The STAP2 (signal transducing adaptor family member 2) is a protein-coding gene located on chromosome 19.
STAP2 is a protein encoded by the STAP2 gene in humans. This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. STAP2 contains domains and tyrosine phosphorylation sites typical of adaptor proteins, which mediate interactions between proteins involved in signal transduction pathways. Multiple transcript variants are produced through alternative splicing. STAP2 has been shown to interact with PTK6.
STAP2 is a substrate of protein kinase PTK6. It might play a role in regulating the acute-phase response during systemic inflammation and could potentially modulate STAT3 activity.
STAP2 is also known as BKS.
