STAM2
Description
The STAM2 (signal transducing adaptor molecule 2) is a protein-coding gene located on chromosome 2.
STAM2, encoded by the STAM2 gene, is a protein closely related to STAM, an adapter protein involved in cytokine receptor signaling. Both proteins contain a SH3 domain and an ITAM motif. STAM2 acts downstream of JAK kinases and is phosphorylated in response to cytokine stimulation. It is believed that STAM2 and STAM have compensatory roles in the signaling pathway downstream of JAK kinases upon cytokine stimulation. STAM2 interacts with HGS, Janus kinase 1, and USP8.
STAM2 plays a crucial role in intracellular signaling pathways triggered by cytokines and growth factors. Upon stimulation with IL-2 and GM-CSF, STAM2 participates in signaling cascades that lead to DNA synthesis and MYC induction. Additionally, STAM2 may contribute to T-cell development. Furthermore, STAM2 is involved in downregulating receptor tyrosine kinases through multivesicular bodies (MVBs) when complexed with HGS, forming the ESCRT-0 complex. This complex binds ubiquitin and acts as a sorting machinery, identifying ubiquitinated receptors and facilitating their transfer to subsequent lysosomal sorting and trafficking processes.
STAM2 is also known as Hbp, STAM2A, STAM2B.
Associated Diseases
- thyroid gland adenocarcinoma
- ovarian cancer
- endometrial cancer
- gastrointestinal stromal tumor
- Miyoshi myopathy
- type 1 diabetes mellitus
- cancer
- alopecia
