STAB1
Description
The STAB1 (stabilin 1) is a protein-coding gene located on chromosome 3.
STAB1 is a transmembrane receptor protein encoded by the STAB1 gene in humans. This protein plays a potential role in angiogenesis, lymphocyte homing, cell adhesion, and receptor scavenging. STAB1 contains numerous domains, including fasciclin, epidermal growth factor (EGF)-like, laminin-type EGF-like, and a C-type lectin-like hyaluronan-binding Link module. Its primary expression is on sinusoidal endothelial cells of the liver, spleen, and lymph nodes. STAB1 has been observed to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its role as a scavenger receptor, STAB1 rapidly cycles between the plasma membrane and early endosomes. STAB1 is also known to interact with the protein chitinase domain-containing protein 1 (CHID1).
STAB1 acts as a scavenger receptor for acetylated low density lipoprotein (LDL), potentially playing a role in defense against bacterial infection by binding to both Gram-positive and Gram-negative bacteria. Inhibition of STAB1 in endothelial tube formation assays results in decreased cell-cell interactions, suggesting its involvement in angiogenesis. STAB1 is also involved in the transport of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
STAB1 is also known as CLEVER-1, FEEL-1, FEEL1, FELE-1, FEX1, HRFT, SCARH2, STAB-1.
