ST3GAL2
Description
The ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2) is a protein-coding gene located on chromosome 16.
ST3GAL2 is a sialyltransferase that catalyzes the transfer of sialic acid from CMP-Neu5Ac to Galbeta-(1->3)-GalNAc-terminated glycoconjugates, forming an alpha2-3 linkage. It plays a key role in the biosynthesis of gangliosides, including GD1a, GM1b, and GT1b. ST3GAL2 is also responsible for the sialylation of SSEA3, forming SSEA4, a pluripotent stem cell- and cancer stem cell-associated antigen. Furthermore, it is involved in the regulation of TLR2 signaling in spinal cord microglia in response to nerve injury.
ST3GAL2 is also known as Gal-NAc6S, SIAT4B, ST3GALII, ST3GalA.2.
Associated Diseases
- COVID-19
- endometrial cancer
- Glanzmann thrombasthenia 1
- beta-thalassemia-X-linked thrombocytopenia syndrome
- reticular dysgenesis
- severe combined immunodeficiency due to CARD11 deficiency
- immunodeficiency 18
- severe combined immunodeficiency due to CTPS1 deficiency
