SSTR3
The SSTR3 Gene: A Gateway to Understanding Neurological and Metabolic Disorders
Description:
The SSTR3 gene, located on chromosome 14 in humans, encodes the somatostatin receptor type 3 (SSTR3). SSTR3 is a member of the G protein-coupled receptor (GPCR) superfamily and plays a crucial role in regulating various physiological functions.
SSTR3 receptors are found in the central and peripheral nervous systems, as well as in the pancreas, gastrointestinal tract, and other tissues. They bind to the neurotransmitter somatostatin, which inhibits the release of hormones and neurotransmitters, including growth hormone, insulin, and glucagon.
Associated Diseases:
Mutations in the SSTR3 gene have been linked to a range of neurological and metabolic disorders:
- Acromegaly: A condition characterized by excessive growth hormone production, leading to abnormal bone growth and gigantism.
- Cushing's syndrome: A disorder caused by an overproduction of the hormone cortisol, resulting in weight gain, high blood sugar, and a rounded or "moon" face.
- Neuroendocrine tumors: Tumors that arise in the hormone-producing glands of the body, including pituitary adenomas (causing acromegaly and Cushing's), pancreatic islet cell tumors, and gastrointestinal neuroendocrine tumors.
- Obesity: Studies suggest that genetic variations in the SSTR3 gene may contribute to an increased risk of obesity.
Did you Know ?
- Approximately 1 in 20,000 individuals worldwide have acromegaly, a condition primarily caused by mutations in the SSTR3 gene.
