SSB
Description
The SSB (small RNA binding exonuclease protection factor La) is a protein-coding gene located on chromosome 2.
SSB (Single-stranded binding protein) is a human gene involved in various cellular processes, including RNA processing, viral infection, and protein interactions. It is also known as La autoantigen, La ribonucleoprotein, and Sjögren syndrome type B antigen. SSB plays a crucial role in the protection and maturation of nascent RNA polymerase III transcripts. Additionally, it participates in the translation of Coxsackievirus B3 by interacting with the viral internal ribosome entry site (IRES). SSB interacts with other proteins, including DDX15 and potentially RUFY1.
SSB binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, SSB binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.
SSB is also known as LARP3, La, La/SSB.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- Alzheimer disease
- cancer
- systemic lupus erythematosus
- cystic fibrosis
- Schwartz-Jampel syndrome
