SRSF7
Description
The SRSF7 (serine and arginine rich splicing factor 7) is a protein-coding gene located on chromosome 2.
SRSF7 is essential for the splicing of pre-mRNA. It can also influence alternative splicing in laboratory settings. SRSF7 inhibits the splicing of exon 10 in the MAPT/Tau gene. It may act as an export adapter in the process of moving mRNA out of the nucleus, such as in the export of histone H2A mRNA. SRSF7 binds to mRNA, which is believed to be transferred to the NXF1-NXT1 heterodimer for export via the TAP/NXF1 pathway. This binding enhances the RNA-binding activity of NXF1-NXT1. SRSF7 exhibits semi-sequence-specific RNA-binding.
SRSF7 is also known as 9G8, AAG3, SFRS7.
Associated Diseases
- cancer
- type 1 diabetes mellitus
- glioblastoma
- Miyoshi myopathy
- spindle cell hemangioma
- acute kidney failure
