SRI
Description
The SRI (sorcin) is a protein-coding gene located on chromosome 7.
Sri, SRI, or variations thereof, may refer to various entities. In the context of human genetics, SRI often refers to the gene encoding the Sorcin protein.
Sorcin is a calcium-binding protein that plays a crucial role in regulating the heartbeat. It helps control the flow of calcium ions, which are essential for muscle contraction. Specifically, Sorcin modulates the activity of RYR2 calcium channels, which are located in the heart's sarcoplasmic reticulum, a specialized organelle that stores calcium. By regulating these channels, Sorcin ensures that the heart contracts efficiently and rhythmically.
SRI is also known as CP-22, CP22, SCN, V19.
Associated Diseases
- type 2 diabetes mellitus
- hyperinsulinism due to INSR deficiency
- type 1 diabetes mellitus
- hyperinsulinism due to glucokinase deficiency
- diabetes mellitus, transient neonatal, 2
- exercise-induced hyperinsulinism
- cancer
- islet cell adenomatosis
- hyperinsulinemic hypoglycemia, familial, 4
- hyperinsulinemic hypoglycemia, familial, 1
- male hypergonadotropic hypogonadism-intellectual disability-skeletal anomalies syndrome
- hyperinsulinemic hypoglycemia, familial, 2
- hyperinsulinism-hyperammonemia syndrome
- hypoinsulinemic hypoglycemia and body hemihypertrophy
- obesity due to prohormone convertase I deficiency
