SRF
Description
The SRF (serum response factor) is a protein-coding gene located on chromosome 6.
SRF may refer to: Serum response factor (SRF)
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 base pairs upstream of the transcription start site of certain genes, such as FOS. In collaboration with the MRTFA transcription coactivator, SRF regulates the expression of genes involved in cytoskeletal organization during developmental processes, morphogenesis, and cell migration. The activity of the SRF-MRTFA complex is responsive to changes in cellular globular actin (G-actin) concentration triggered by Rho GTPases, effectively linking cytoskeletal gene expression to dynamic changes in the cytoskeleton. SRF is essential for cardiac differentiation and maturation.
SRF is also known as MCM1.
