SPOPL
Description
The SPOPL (speckle type BTB/POZ protein like) is a protein-coding gene located on chromosome 2.
SPOPL is a component of a cullin-RING-based E3 ubiquitin ligase complex, specifically the BCR (BTB-CUL3-RBX1) type. This complex plays a role in tagging target proteins for degradation by the proteasome. However, SPOPL's involvement in this process is relatively inefficient compared to other components of the complex. When SPOPL forms homodimers or heterodimers with SPOP, the resulting ubiquitin ligase complexes exhibit lower activity than those containing only SPOP. This suggests that SPOPL might act as a regulator, potentially downregulating the activity of the complex containing SPOP.
SPOPL is also known as BTBD33.
Associated Diseases
- multiple sclerosis
- autosomal recessive spondylocostal dysostosis
- Prata-Liberal-Goncalves syndrome
- osteomesopyknosis
- primary basilar invagination
- Mobius syndrome
- cancer
- inherited lipid metabolism disorder
