SPIC
Description
The SPIC (Spi-C transcription factor) is a protein-coding gene located on chromosome 12.
SPIC is a gene that encodes a protein involved in the development of red pulp macrophages, which are important for red blood cell recycling and iron homeostasis.
SPIC plays a crucial role in the development of red pulp macrophages, which are essential for recycling red blood cells and maintaining iron balance in the body. It functions as a transcription factor, binding to a specific DNA sequence known as the PU-box, a purine-rich region that acts as an enhancer in lymphoid cells. Additionally, SPIC regulates the expression of the VCAM1 gene, although the exact mechanism is not fully understood.
SPIC is also known as SPI-C.
Associated Diseases
- BENTA disease
- beta-thalassemia-X-linked thrombocytopenia syndrome
- dominant beta-thalassemia
- hemoglobin H disease
- erythroleukemia, familial, susceptibility to
- autoimmune lymphoproliferative syndrome type 4
- hemoglobin C-beta-thalassemia syndrome
- hereditary neutrophilia
- neutropenia-monocytopenia-deafness syndrome
- sideroblastic anemia 3
- severe combined immunodeficiency due to LAT deficiency
