SPATA3
SPATA3 Gene: A Comprehensive Guide
Description
The SPATA3 gene (Spermatozoa Associated 3) is located on the X chromosome and plays a crucial role in male fertility. It encodes a protein of the same name that is essential for the formation and function of sperm. SPATA3 is particularly involved in the development of the sperm's tail, which is responsible for its motility and ability to reach the egg for fertilization.
Associated Diseases
Mutations in the SPATA3 gene have been associated with several fertility-related disorders in males, including:
- Azoospermia: A condition where no sperm are produced in the semen.
- Oligozoospermia: A condition where the semen contains a low number of sperm.
- Asthenozoospermia: A condition where the sperm are weak or have poor motility.
- Teratozoospermia: A condition where the sperm have an abnormal shape or structure.
Did you Know ?
Approximately 1 in 2,500 males worldwide have mutations in the SPATA3 gene, making it one of the most common genetic causes of male infertility. This highlights the significant impact that the SPATA3 gene plays in ensuring successful reproduction.
