SPATA24
The spata24 Gene: Unraveling Its Role in Human Health
Description
The spata24 gene, located on chromosome 15q25.1, encodes a protein known as sperm-associated antigen 24 (SPATA24). This protein is primarily expressed in the male germ cells during spermatogenesis, the process of sperm production. SPATA24 is involved in various cellular functions crucial for sperm maturation and fertilization.
Associated Diseases
Mutations in the spata24 gene have been linked to several male infertility disorders, including:
- Azoospermia: Absence of sperm in the semen
- Oligospermia: Low sperm count
- Asthenozoospermia: Reduced sperm motility
- Teratozoospermia: Abnormal sperm morphology
These mutations can disrupt the normal functioning of SPATA24, impairing sperm production and affecting male fertility.
Did you Know ?
Approximately 1-2% of all male infertility cases are attributed to mutations in the spata24 gene, highlighting its significance in male reproductive health.
