SPAG9
Description
The SPAG9 (sperm associated antigen 9) is a protein-coding gene located on chromosome 17.
SPAG9, also known as JIP-4, is a scaffold protein that plays a crucial role in cell signaling. It facilitates the interaction of mitogen-activated protein kinases (MAPKs) and their transcription factor targets, leading to the activation of specific signaling pathways. SPAG9 is highly expressed in testicular haploid germ cells and is recognized by sperm-agglutinating antibodies, suggesting a role in infertility. It is a potential biomarker for early detection of various cancers, including cervical carcinoma, bladder cancer, and lung cancer.
SPAG9, also known as JIP-4, plays a crucial role in mediating JNK signaling by bringing together specific components of the MAPK cascade to form a functional signaling module. This protein acts as an adapter protein, linking PIP4P1-positive lysosomes to the dynein-dynactin complex, thereby regulating lysosomal positioning. SPAG9 also assists PIKFYVE in microtubule-based endosome-to-TGN trafficking.
SPAG9 is also known as CT89, HLC-6, HLC4, HLC6, JIP-4, JIP4, JLP, PHET, PIG6.
Associated Diseases
- endometrial cancer
- male infertility with teratozoospermia due to single gene mutation
- nonpapillary renal cell carcinoma
- spermatogenic failure 7
- spermatogenic failure 10
- spermatogenic failure 11
- spermatogenic failure 70
- spermatogenic failure 65
- spermatogenic failure 47
- spermatogenic failure 40
- spermatogenic failure, X-linked, 3
- spermatogenic failure 41
- spermatogenic failure 39
- spermatogenic failure 29
- spermatogenic failure 51
