SP1
Description
The SP1 (Sp1 transcription factor) is a protein-coding gene located on chromosome 12.
SP1 and variants may refer to:
SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. It binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. SP1 is highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). It also binds the PDGFR-alpha G-box promoter. SP1 may have a role in modulating the cellular response to DNA damage and is implicated in chromatin remodeling. It plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, SP1 maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. SP1 positively regulates the transcription of the core clock component BMAL1. It plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. SP1 plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112. {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}
SP1 is also known as -.
