SOX7
Description
The SOX7 (SRY-box transcription factor 7) is a protein-coding gene located on chromosome 8.
SOX7 is a member of the SOX family of transcription factors that plays a key role in embryonic development and cell fate determination. It regulates gene expression by forming protein complexes with other factors and is potentially involved in tumorigenesis. While the specific function of human SOX7 is still under investigation, research suggests it is involved in the regulation of the Wnt pathway and has tumor-suppressive effects. SOX7, along with SOX17 and SOX18, is involved in cardiovascular development, particularly in hematopoiesis, vasculogenesis, and cardiogenesis.
SOX7 binds to and activates the CDH5 promoter, which plays a role in regulating gene expression within the hemogenic endothelium. This action prevents the differentiation of these cells into blood precursors. Additionally, SOX7 may be necessary for the survival of both hematopoietic and endothelial precursor cells during their development. It competes with GATA4 for binding to and activating the FGF3 promoter, and it also represses Wnt/beta-catenin-stimulated transcription by targeting CTNNB1 for degradation. SOX7 binds to the DNA sequence 5'-AACAAT-3'.
SOX7 is also known as -.
