SOX4
Description
The SOX4 (SRY-box transcription factor 4) is a protein-coding gene located on chromosome 6.
SOX4 is a gene that encodes a protein called SOX4, a member of the SOX family of transcription factors. These factors are essential for regulating embryonic development and cell fate. SOX4 works by binding to DNA and activating or repressing genes. It has been linked to cell death, tumor formation, and bone development. Specifically, SOX4 interacts with syntenin, a protein involved in cell signaling, and may play a role in the apoptosis pathway. It also mediates the effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone growth. SOX4 is expressed in B and T lymphocytes and is crucial for B cell development. A region near the SOX4 gene has been associated with endometrial cancer. SOX4 interacts with SDCBP, a protein that binds to syndecans, which are cell surface molecules involved in cell signaling.
SOX4 acts as a transcriptional activator, binding strongly to the T-cell enhancer motif 5'-AACAAAG-3' (PubMed:30661772). It's essential for the maturation and development of IL17A-producing Vgamma2-positive gamma-delta T-cells, achieved by binding to regulatory regions of RORC to control expression (By similarity). SOX4 plays a role in skeletal myoblast differentiation by stimulating the expression of CALD1 (PubMed:26291311). {ECO:0000250|UniProtKB:Q06831, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:30661772}
SOX4 is also known as CSS10, EVI16.
