SOX15
Description
The SOX15 (SRY-box transcription factor 15) is a protein-coding gene located on chromosome 17.
SOX15 is a protein encoded by the SOX15 gene in humans. This gene belongs to the SOX (SRY-related HMG-box) family of transcription factors that play a crucial role in embryonic development and cell fate determination. The SOX15 protein may function as a transcriptional regulator by forming a complex with other proteins.
SOX15 is a transcription factor that binds to the DNA sequence 5'-AACAATG-3'. It can act as both a transcriptional activator and repressor. SOX15 can bind synergistically with POU5F1 (OCT3/4) to gene promoters. It binds to the FOXK1 promoter, recruits FHL3, and activates FOXK1 transcription, leading to myoblast proliferation. However, SOX15 also inhibits myoblast differentiation by repressing the expression of the muscle-specific genes MYOD and MYOG. It is involved in trophoblast giant cell differentiation by enhancing HAND1 transcriptional activity and regulates the transcription of HRC by binding to its proximal enhancer region. SOX15 plays a role in skeletal muscle regeneration and the development of myogenic precursor cells.
SOX15 is also known as SOX20, SOX26, SOX27.
