SOGA1
SOGA1 Gene: A Guardian of Cellular Homeostasis
Description
The SOGA1 gene is a crucial player in the intricate network of cellular processes that maintain the balance and health of our bodies. Located on chromosome 3, SOGA1 encodes the Suppressor of G2 Allele of SKP1 (SOGA1) protein, a pivotal regulator of cell cycle progression, cellular proliferation, and genome integrity.
Associated Diseases
Disruptions in the normal functioning of the SOGA1 gene have been linked to several human diseases, including:
- Microcephaly: Characterized by an unusually small head circumference, microcephaly can result from mutations in the SOGA1 gene that disrupt the proper development of the brain.
- Seckel Syndrome: A rare genetic disorder that affects fetal growth and causes distinctive facial features and skeletal abnormalities, Seckel Syndrome is often caused by SOGA1 gene mutations.
- Cancer: Mutations in SOGA1 have been associated with increased risk for certain types of cancer, such as esophageal squamous cell carcinoma and colorectal cancer.
Did you Know ?
Approximately 1 in 10,000 individuals worldwide are estimated to have a genetic mutation in the SOGA1 gene. This highlights the gene's significance in maintaining human health and the potential impact of its dysfunction on a global scale.
