SNX5
Description
The SNX5 (sorting nexin 5) is a protein-coding gene located on chromosome 20.
SNX5, the gene encoding sorting nexin-5, is a member of the sorting nexin family involved in intracellular trafficking. It contains a phox (PX) domain, which binds to phosphoinositides, and is part of the retromer complex, facilitating cargo retrieval from endosomes to the trans-Golgi network. SNX5 also binds to the Fanconi anemia, complementation group A protein. Two transcript variants of SNX5 encode the same protein.
SNX5 is involved in various stages of intracellular trafficking. It interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). SNX5 is a component of the retromer membrane-deforming SNX-BAR subcomplex, which mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex deforms the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). SNX5 does not have in vitro vesicle-to-membrane remodeling activity. It is involved in retrograde transport of the lysosomal enzyme receptor IGF2R. SNX5 may function as a link between endosomal transport vesicles and dynactin. It plays a role in the internalization of EGFR after EGF stimulation. SNX5 is involved in EGFR endosomal sorting and degradation; this function involves PIP5K1C isoform 3 and is retromer-independent. SNX5, together with PIP5K1C isoform 3, facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. SNX5 is involved in E-cadherin sorting and degradation; it inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. SNX5 plays a role in macropinocytosis.
SNX5 is also known as -.
