SNX4
Description
The SNX4 (sorting nexin 4) is a protein-coding gene located on chromosome 3.
SNX4, encoded by the SNX4 gene, is a member of the sorting nexin family. These proteins contain a PX domain, which binds phosphoinositides, and play a role in intracellular trafficking. SNX4 has been observed to associate with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its specific function remains unclear. SNX4 may form oligomeric complexes with other family members. SNX4 has been shown to interact with BIN1.
SNX4 is involved in the regulation of endocytosis and various stages of intracellular trafficking. It plays a role in recycling endocytosed transferrin receptors, preventing their degradation. SNX4 is also involved in autophagosome assembly by regulating the trafficking and recycling of phospholipid scramblase ATG9A.
SNX4 is also known as ATG24B.
