SNX15
Description
The SNX15 (sorting nexin 15) is a protein-coding gene located on chromosome 11.
SNX15 is a protein encoded by the SNX15 gene in humans. It belongs to the sorting nexin family, characterized by a PX domain that binds phosphoinositides and plays a role in intracellular trafficking. SNX15 overexpression leads to a decrease in the processing of insulin and hepatocyte growth factor receptors due to mislocalization of furin, the enzyme responsible for their cleavage. SNX15 is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the TGN. The SNX15 gene produces two transcript variants encoding distinct isoforms.
SNX15 is involved in intracellular trafficking, particularly in the movement of proteins from the plasma membrane to recycling endosomes or the trans-Golgi network (TGN). Overexpression of SNX15 disrupts this normal trafficking process.
SNX15 is also known as HSAF001435.
Associated Diseases
- cholesterol-ester transfer protein deficiency
- hypertriglyceridemia 2
- hyperinsulinism due to INSR deficiency
- glycogen storage disease VI
- familial apolipoprotein C-II deficiency
- hyperinsulinism due to HNF1A deficiency
- cancer
- Huntington disease
