SNF8
Description
The SNF8 (SNF8 subunit of ESCRT-II) is a protein-coding gene located on chromosome 17.
Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.
SNF8 is a component of the ESCRT-II complex, which is crucial for the formation of multivesicular bodies (MVBs) and the sorting of endosomal cargo proteins into MVBs. The MVB pathway plays a role in delivering transmembrane proteins to the lysosome for degradation. The ESCRT-II complex is likely involved in recruiting the ESCRT-III complex. Additionally, it might contribute to transcription regulation by participating in the derepression of RNA polymerase II transcription, potentially through its interaction with ELL. SNF8 is required for the degradation of endocytosed EGF and EGFR, but not for the ligand-mediated internalization of EGFR. It is also necessary for the degradation of CXCR4 and the exosomal release of SDCBP, CD63, and syndecan. These findings are supported by various publications including PubMed:17714434, PubMed:17959629, PubMed:18031739, and PubMed:22660413.
SNF8 is also known as DEE115, Dot3, EAP30, NEDOA, VPS22.
