SND1
Description
The SND1 (staphylococcal nuclease and tudor domain containing 1) is a protein-coding gene located on chromosome 7.
SND1, or Staphylococcal nuclease domain-containing protein 1, is a protein encoded by the SND1 gene. It is a key component of the RISC complex and plays a crucial role in miRNA function. SND1 is a Tudor domain-containing protein, a highly conserved protein family found even in organisms like Drosophila melanogaster. SND1 is also linked to Autism. Clinically, SND1 acts as an oncogene in various cancers, particularly in hepatocellular carcinoma progression. It promotes tumor angiogenesis via a novel pathway involving NF-kappaB and miR-221. Furthermore, SND1 promotes cell migration and invasion through angiotensin II type 1 receptor and TGFβ signaling. Its expression is regulated by Mir-184 in gliomas. SND1 interacts with various proteins, including MYB, PIM1, POLR2A, RBPJ, STAT6, G3BP (stress granule protein), and AEG-1.
SND1 is an endonuclease that mediates the decay of both protein-free and AGO2-loaded miRNAs, playing a role in regulating mRNAs involved in the G1-to-S phase transition. It acts as a bridging factor between STAT6 and the basal transcription factor, and participates in PIM1 regulation of MYB activity. Additionally, SND1 functions as a transcriptional coactivator for STAT5.
SND1 is also known as TDRD11, TSN, Tudor-SN, p100.
