SNCG
Description
The SNCG (synuclein gamma) is a protein-coding gene located on chromosome 10.
Gamma-synuclein is a protein encoded by the SNCG gene in humans. It belongs to the synuclein family, which is thought to be involved in neurodegenerative diseases. High levels of SNCG have been found in advanced breast carcinomas, suggesting a correlation between its overexpression and breast tumor development. Gamma-synuclein is primarily found in the peripheral nervous system (sensory, sympathetic, and motor neurons) and retina. It is also detected in the brain, ovarian tumors, and olfactory epithelium. Gamma-synuclein is the least conserved synuclein protein. Its expression in breast tumors is a marker for tumor progression, as it was first identified as breast cancer-specific gene 1 (BCSG1). A change in gamma-synuclein expression has been observed in the retina of patients with Alzheimer's disease. The normal cellular function of gamma-synuclein remains unknown.
SNCG is also known as BCSG1, SR.
