SMYD3
Description
The SMYD3 (SET and MYND domain containing 3) is a protein-coding gene located on chromosome 1.
SMYD3 is a protein encoded by the SMYD3 gene in humans. It acts as a lysine methyltransferase, specifically targeting H3K4 and H4K5, and plays a crucial role in transcriptional regulation as part of an RNA polymerase complex. SMYD3 is highly expressed in skeletal muscles and the testis and is implicated in cancer regulation. This protein interacts with Heat shock protein 90kDa alpha (cytosolic), member A1 and POLR2A. SMYD3's methylation of MAP3K2 contributes to the MAP kinase signaling pathway, particularly in Ras-driven cancers. Its overexpression in various cancers, including liver, breast, colorectal, lung, esophageal, and prostate cancers, highlights its importance in cancer progression. In lung and colorectal cancers, SMYD3-mediated methylation of MAP3K2 disrupts PPA2's inhibitory control, activating the MEK/ERK signaling cascade and overriding apoptosis signals.
SMYD3 is a histone methyltransferase that specifically modifies lysine 4 of histone H3, leading to di- and tri-methylation but not monomethylation. It also methylates lysine 5 of histone H4. SMYD3 plays a crucial role in transcriptional activation as part of an RNA polymerase complex. This protein binds to DNA sequences containing 5'-CCCTCC-3' or 5'-GAGGGG-3'.
SMYD3 is also known as KMT3E, ZMYND1, ZNFN3A1, bA74P14.1.
Associated Diseases
- systemic lupus erythematosus
- cerebellar dysfunction with variable cognitive and behavioral abnormalities
- cancer
- breast cancer
- Mobius syndrome
- major depressive disorder
