SMIM20


Description

The SMIM20 (small integral membrane protein 20) is a protein-coding gene located on chromosome 4.

SMIM20 is a protein encoded by the SMIM20 gene in humans. It acts as a prohormone to the peptide hormone phoenixin, first discovered in 2013 in rodent sensory ganglia. SMIM20 and NUCB2 exhibit deep homology across various lineages, including bilaterians, cnidarians, ctenophores, sponges, and choanoflagellates, indicating their significance in the evolution of nervous systems.

SMIM20 is a component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex), which regulates cytochrome c oxidase assembly. It promotes the progression of complex assembly after MT-CO1/COX1 associates with COX4I1 and COX6C. As a chaperone-like assembly factor, SMIM20 stabilizes newly synthesized MT-CO1/COX1 and prevents its premature turnover.

SMIM20 is also known as C4orf52, MITRAC7, PNX.

Associated Diseases



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