SMIM19
Description
The SMIM19 (small integral membrane protein 19) is a protein-coding gene located on chromosome 8.
SMIM19, also known as Small Integral Membrane Protein 19, encodes the SMIM19 protein. SMIM19 is a confirmed single-pass transmembrane protein passing from outside to inside, 5' to 3' respectively. SMIM19 has ubiquitously high to medium expression with among varied tissues or organs. The validated function of SMIM19 remains under review because of on sub-cellular localization uncertainty. However, all linked proteins research to interact with SMIM19 are associated with the endoplasmic reticulum (ER), presuming SMIM19 ER association
== Gene == SMIM19 is also commonly known and referenced as C8orf40 (chromosome 8 open reading frame 40). SMIM19 also has a few other lesser known names, such as LOC114926, Doyzeeby, and Beeveybu. The SMIM19 gene is located on the plus strand at 8p11.21 in humans. The SMIM19 gene is composed of 4 total exons and spanning 14.04 kb from 42,541,155 bp to 42,555,193 bp. The upstream neighboring gene to SMIM19 is SLC20A2.
== Transcripts ==
=== Variants === There are four validate transcript variants for SMIM19 that all encode the same protein, as they only differ in sequence within the 5' UTR. Transcript variant 1 represents the longest transcript
=== Features === The SMIM19 mRNA is composed of one major polyadenylation sequence and site combination and three alternative ones, along with an upstream in-frame stop codon.
The exact function of SMIM19 remains under investigation due to uncertainty about its subcellular localization. However, all known interacting proteins are associated with the endoplasmic reticulum (ER), suggesting that SMIM19 may also be localized to the ER.
SMIM19 is also known as C8orf40.
