SMIM14
Description
The SMIM14 (small integral membrane protein 14) is a protein-coding gene located on chromosome 4.
SMIM14, also known as Small integral membrane protein 14 or C4orf34, is a protein encoded on chromosome 4 of the human genome by the SMIM14 gene. SMIM14 has at least 298 orthologs mainly found in jawed vertebrates and no paralogs. SMIM14 is classified as a type I transmembrane protein. While this protein is not well understood by the scientific community, the transmembrane domain of SMIM14 may be involved in ER retention.
== Gene == The SMIM14 gene is located on the minus strand at cytogenetic band 4p14 and is 92,567 base pairs in length. The gene has five exons, four of which constitute the open-reading frame for SMIM14. The Kozak sequence, which functions as the protein translation initiation site in most eukaryotic mRNA transcripts, is considered a strong motif. There is no signal peptide in SMIM14, but the encoded transmembrane domain acts as the signal sequence. It is predicted that one disulfide bridge is encoded in SMIM14, which stabilizes the tertiary (and sometimes quaternary) structures of proteins. There are at least ten polyadenylation sequences in the 3’ UTR of the SMIM14 gene, indicating transcription termination.
The function of SMIM14 is not yet fully understood, but it is known to be a type I transmembrane protein. Its transmembrane domain may play a role in ER retention, suggesting potential involvement in protein trafficking or ER function. Further research is needed to elucidate its precise role in cellular processes.
SMIM14 is also known as C4orf34.
